Dr. Francisco Sarabia

Department of Organic Chemistry

University of Malaga

Exploring New Synthetic Methodologies for the Asymmetric Synthesis of Natural Products

The lecture will focus on recent advances in asymmetric synthesis of natural products of biological interest accomplished by the research group. An important part of the lecture will deal with the development of a new type of chiral sulfonium salts and their applications in stereoselective synthesis of various natural products and analogues thereof. These natural products include the bengamides, depudecin, gummiferol, pironetin, globomycin and crocacin. On the other hand, recent contributions on new synthetic methodologies for construction of complex scaffolds will be reported. These new synthetic methodologies were successfully applied in total synthesis of complex nucleoside-type antibiotics, such as the tunicamycins.

Dr. Francisco Sarabia received his PhD degree from University of Málaga (Spain) in 1994 under the supervision of Prof. López-Herrera. After postdoctoral research with Prof. K. C. Nicolaou at the Scripps Research Institute in La Jolla (1995-1997), he returned to the University of Málaga in 1998 as assistant professor, where he was promoted to Full Professor in 2011. Prof. Sarabia has been visiting professor in the Technological Institute of Zürich (ETH) in 1998 with Prof. A. Vasella, The Scripps Research Institute in 2001 with Prof. Nicolaou, Scripps Florida in 2013 with Prof. W. R. Roush and more recently, at Broad Institute in collaboration with Prof. Schreiber. He is the Head of the Department of Organic Chemistry since 2014, scientific responsible of the NMR facilities of the University of Málaga and, since 2020, the Academic Coordinator of UNED at Malaga. His research interests include total synthesis of natural products, development of new synthetic methodologies and medicinal chemistry and discovery of new bioactive compounds. As result of his research activity, Francisco Sarabia has published more than 100 articles and he is the co-inventor of various patents.

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